Preventing vision loss globally with advanced research and development
Developing next generation treatments to preserve vision for patients with diseases affecting the back of the eye
Oxurion at a glance
Oxurion is a biopharmaceutical company that has engineered a diverse portfolio of disease-modifying drug candidates, including treatments for diabetic eye disease, a leading cause of blindness in people of working age worldwide.
Oxurion owns the global rights to Jetrea (ocriplasmin), the only pharmacological vitreolysis drug approved for the treatment of symptomatic vitreomacular adhesion (in the U.S.) and vitreomacular traction (outside the U.S.).
Oxurion is headquartered in Leuven, Belgium, and is listed on Euronext Brussels under the symbol OXUR.
Positive Topline Data for Phase 1 Results with THR-149 for treating dME
Oxurion NV Reports Positive Topline Phase 1 Results with THR-149, a novel, potent plasma kallikrein inhibitor for the treatment of DME.
Enrollment complete for Phase 2 clinical study for treating DME
Oxurion NV announces full enrollment of its Phase 2 trial evaluating efficacy and safety of the combination of anti-PlGF (THR-317) and anti-VEGF (ranibizumab) for the treatment of DME, ahead of...
Oxurion and Beta Therapeutics to develop new heparanase inhibitors for treatment of dry AMD
First Patient enrolled in Phase II Clinical Study Evaluating THR-317 for treatment of MacTel 1
The study evaluates the efficacy and safety of THR-317 for the treatment of Macular Telangiectasia Type 1. This is a rare disease that affects the macula and can lead to vision loss.
First Patient enrolled in Phase I Clinical Trial of THR-687 for Treatment of DME
Preclinical studies have demonstrated the role of THR-687 (a pan RGD integrin antagonist) in targeting multiple aspects of retinal disease such as vessel leakage, inflammation, and neovascularization.
ThromboGenics becomes Oxurion
Initiation of a Phase II clinical trial evaluating THR-317 incombination with Lucentis (anti-VEGF)
Positive data from THR-317 Phase I/IIa clinical trial
The data confirm a good safety and tolerability of THR-317, and a clinically relevant biological activity.
First patients recruited in a Phase I/IIa clinical trial evaluating THR-317 (anti-PlGF) for treatment of DME.
The company regains full global commercial rights to its product JETREA®
Through an agreement with Novartis, the company regains full global commercial rights to JETREA®. Under the terms of the agreement, the company receives a forthcoming equity investment of €10 million.
Oncurious recruits first patient in trial with TB-403
Oncurious recruits its first patient in a Phase I/IIa clinical trial evaluating TB-403 (anti-PlGF) for treatment of medulloblastoma, a rare and life-threatening brain tumor that affects children.
Investor meeting on novel disease-modifying approaches for diabetic eye disease
The approach has a current focus on diabetic eye disease, mainly diabetic retinopathy/diabetic macular edema, while providing a platform to develop therapies for other ophthalmological indications.
Creation of Oncurious NV for oncology research
New pathways: drug development for diabetic eye disease
In 2015, ThromboGenics took a strategic decision to focus its resources on drug development. This decision was driven by the significant potential of our exciting and broad pipeline of next-...
JETREA® approval in over 50 countries worldwide
EU approval and commercial launch of JETREA® outside the U.S.
European Medicines Agency (EMA) approves JETREA® (Ocriplasmin) for the Treatment of vitreomacular traction (VMT). Alcon launches JETREA in the first markets in Europe.
Commercial launch of JETREA® in the U.S.
US FDA Approval for ocriplasmin
The FDA approves ocriplasmin for the treatment of symptomatic vitreomacular adhesion (VMA) in the United States.
Patrik De Haes, MD, appointed CEO
Ocriplasmin for vitreoretinal indications
ThromboGenics listed on Euronext Brussels
ThromboGenics broadens the company's R&D scope to include cardiovascular, oncology and ophthalmology programs in-licensed from the University of Leuven and the Flanders Institute for...
In 1991, Prof. Dr. Désiré Collen and colleagues at Katholieke Universiteit Leuven create Thromb-X NV, with an initial focus on the cardiovascular space.
Our goal is to prevent vision loss and fight blindness worldwide by developing and delivering next-generation treatments in ophthalmology. We aim to lower the burden of treatment for patients and enhance practice management for physicians. We develop innovative compounds that each target a distinct, unexplored pathway to answer unmet medical needs in ophthalmology, with a focus on back of the eye disease.
Our current pipeline of unique drug candidates is focused on new treatment approaches for diabetic eye disease, and we will continue leveraging our expertise in diseases affecting the back of the eye to expand our pipeline to address additional indications with high unmet needs. We are committed to innovation through cross-disciplinary and cooperative research across the globe. Collaborating with stakeholders worldwide, we aim to deliver solutions enabling equal, affordable vision preservation for all people.
Part of a global community
Oxurion’s engagement reaches far beyond R&D and the promotions of new therapies. Through sustainable partnerships with social initiatives ‑ medical charity, education, culture - Oxurion is committed to increasing patient access to therapies for disorders affecting the back of the eye. Together, we set our sights on providing a better quality of life to those in need.
Retina Global: Oxurion has supported certification courses in diabetic retinopathy for ophthalmologists and ophthalmology residents in Bolivia. Retina Global is an international nonprofit focused on sustainable solutions for retinal services in underserved areas around the world.
Prevent Blindness: Oxurion has partnered with Prevent Blindness at the 2018 Focus on Eye Health national summit in Washington, DC. For over a century, the organization has been working to prevent blindness and preserve sight.
Light for the World: Oxurion has supported the Belgian branch of this European NGO since 2014. The organization fights eye disease in Rwanda, Tanzania and Congo, providing organizational, technical and financial support to medical eye centers.
People at Oxurion
Oxurion employs 78 people worldwide, all are united by a shared goal: to make Oxurion a global leader in developing and commercializing innovative treatments for chronic eye disorders.
Most members of the Oxurion international team hold a master’s or PhD degree. The majority work at our headquarters in Leuven (Belgium) or from our office in New Jersey (U.S.).
Each member of the Oxurion team provides a distinct viewpoint and set of experiences in the biopharmaceutical industry. The diversity and experience of the team stimulates creativity and problem-solving while enabling the company to successfully develop and commercialize therapeutics to preserve the vision of patients worldwide.
Thomas Clay is Vice-President of East Hill Management Company, LLC and Chairman and CEO of Golden Queen Mining Co., Ltd. He also serves as a Director of the Clay Mathematics Institute, Inc. Thomas is a graduate of Harvard College, Oxford University, and Harvard Business School, following in the footsteps of his father, Landon Clay, who led the first external investment into Oxurion until leaving the Board in 2011.
Patrik De Haes, MD
Chief Executive Officer, Executive Director
Patrik De Haes, MD, has over 25 years of experience in the global healthcare industry in product development, marketing and general management. Before joining the company as CEO in 2008, Patrik was Head of Roche's Global Insulin Infusion business. Prior to that he was President and CEO of Disetronic Medical Systems Inc., a medical device company based in Minneapolis, USA. He also led the global development and commercialization of the first biotech product at Sandoz Pharma (now Novartis) in Switzerland. Past Chairman of FlandersBio, Patrik is an active member of Belgium's local and regional biotech and life science community. He is also Executive Chairman of Oncurious NV, an oncology company co-created by Oxurion and VIB LIfesciences. Patrik holds a degree in Medicine from the University of Leuven.
Adrienne Graves, PhD
Dr. Adrienne Graves is a board member of multiple companies and organizations including Akorn Inc., Nicox, the American Society of Cataract and Refractive Surgery, the Glaucoma Research Foundation, and the American Academy of Ophthalmology. She was the president and chief executive officer of Santen Inc., the U.S. arm of Japan’s largest ophthalmic pharmaceutical company, Santen Pharmaceutical Co., Ltd. Before becoming the president and chief executive officer, she was the vice president of clinical affairs and senior vice president of worldwide clinical affairs for Japan, U.S. and Europe at Santen Inc. Prior to Santen Inc., Dr. Graves was the director of international ophthalmology at Alcon Laboratories, Inc. She was also the co-founder of Glaucoma 360 (Glaucoma Research Foundation) and Ophthalmic Women Leaders (OWL).
Dr. Graves received her bachelor’s degree in psychology with honors from Brown University, her Ph.D. from the University of Michigan in psychobiology and completed a postdoctoral fellowship in visual neuroscience from the University of Paris.
David Guyer, MD
David Guyer, MD, is a long-standing member of the US retina community. He is Co-Founder and Executive Chairman of the Ophthotech Corporation, where he was previously CEO. Dr. Guyer is also on the boards of Sound Pharmaceuticals, iStar, and PanOptica. He co-founded and served as CEO and as a director of Eyetech Pharmaceuticals, Inc., which he led through private, public and corporate financings. He also oversaw the rapid development and successful commercialization of Macugen® (pegaptanib sodium), the first FDA-approved anti-VEGF pharmacological treatment for treatment of wet AMD. Dr. Guyer had a successful career in academic medicine as Professor and Chairman of the Department of Ophthalmology at New York University School of Medicine. Dr. Guyer received his Bachelor of Science (BSc) degree from Yale College summa cum laude and his medical degree (MD) from Johns Hopkins Medical School. He completed his ophthalmology residency at Wilmer Ophthalmological Institute at Johns Hopkins Hospital and a retinal fellowship at the Massachusetts Eye and Ear Infirmary at Harvard Medical School.
Non-Executive, Independent Director
Emmanuèle Attout was an audit partner at PricewaterhouseCoopers from 1994 to 2014, overseeing audits of a range of clients including banks, insurance companies, investment funds and asset managers. In recent years she managed the audits of listed companies and pharmaceutical and life sciences companies, giving her the substantial experience that she now brings to the Board and the Audit Committee. Emmanuèle is an independent non-executive director and member of the audit committees of Atenor SA and Schréder SA. She is co-founder and since 2009 director of the NGO Women on Board. She is on the board of Toutes à l'école Belgique asbl. Emmanuèle graduated in Applied Economic Sciences from the Catholic University of Louvain.
Baron Philippe Vlerick
Non-Executive, Independent Director
Philippe Vlerick is the owner, Chairman and CEO of several businesses in Belgium and abroad. He is currently Chairman and CEO of Vlerick Group (Belgium), Chairman and CEO of UCO NV, Chairman of Pentahold, Chairman of the Smartphoto Group, Chairman of the Festival Van Vlaanderen, and Commissioner-General of Europalia Romania. Baron Vlerick is Vice Chairman of the KBC Group, Corelio, and Durabilis, and a member of the boards of directors of Exmar, Hamon & Cie, Besix Group, BMT, Etex and L.V.D. (Belgium). Mr. Vlerick holds a degree in Philosophy and Law from the University of Leuven and an MBA in General Management (PUB) (Ghent, Vlerick School of Management – 1979). He also holds an MBA from Indiana University, Bloomington, USA (1980). He was chosen 2006 Manager of the Year by Trends, a leading business magazine in Belgium. He was granted the title of Baron in 2008 and became Commander of the Order of Leopold in 2013.
Patrik De Haes, MD
Chief Executive Officer
Patrik De Haes, MD, has over 25 years of experience in the global healthcare industry in product development, marketing and general management. Before joining Oxurion as CEO in 2008, Patrik was head of Roche’s Global Insulin Infusion division. Prior to that he was President and CEO of Disetronic Medical Systems Inc., a medical device company based in Minneapolis, USA. He also led the global development and commercialization of the first biotech product at Sandoz Pharma (now Novartis) in Switzerland. Patrik holds a degree in Medicine from the University of Leuven.
Chief Financial Officer
Dominique Vanfleteren has over 25 years of experience in senior finance, operational, control and reporting roles in quoted international biopharmaceutical companies. Before joining Oxurion, Dominique spent 12 years at UCB, a global biopharmaceutical company, where he held a number of international managerial finance positions, the latest in Brussels and Shanghai as CFO of UCB’s Asia Pacific Operations. Prior to UCB, he worked for GSK for 16 years in senior finance positions in Brussels and London, the latest as Finance Director of GSK’s Diversified Healthcare Services Europe. Dominique holds a bachelor's degree in Civil Engineering and a master's in Applied Economics (UCL).
Chief Commercial Officer
Vinciane has over 15 years of experience in a variety of sales and marketing leadership roles in the global pharmaceutical industry, the latest being the Head of the Ophthalmology Franchise Europe at Novartis AG. She obtained a master degree in business engineering at the University of Mons-Hainaut.
Jean Feyen, PhD
Chief Scientific Officer
Dr. Feyen oversees all preclinical activities at Oxurion. He joined the company in October 2013 from Galapagos, where he was the VP for alliance and portfolio management. He started his professional career with an academic appointment at the University of Connecticut Health Center. After that, he held several positions in the pharmaceutical and biotech industries. Jean progressed through the ranks in several drug discovery positions in Switzerland and the US, finally heading the translational science and disease biology effort on cardiovascular and metabolic disease at Bristol-Myers Squibb. Jean holds a PhD from the University of Leiden and is an inventor on several patents. He has authored more than sixty peer-reviewed publications. Jean is currently an adjunct professor in the department of pharmacology at the University of Medicine and Dentistry of New Jersey.
Chief Legal Officer
Bio Claude Sander
Andy De Deene, MD
Global Head of Development
Andy De Deene has extensive experience in drug development, including clinical development, pharmacovigilance and medical affairs. He previously worked as both Manager and Director for the Janssen Research Foundation and XCellentis in Belgium. Andy holds an MD from the University of Ghent, trained as a dermatologist at the University of Cologne, and obtained an executive MBA from Vlerick Management School.
Oxurion relies on a network of experienced partners to bring the best possible eye care to patients across the globe. These partnerships include research collaboration, co-development, co-commercialization, and in-licensing agreements.
We are always open to new opportunities for partnership and collaboration for improving eye care.
Oxurion is focused on developing innovative medicine and continues to broaden its activities through strategic research projects, joint development, licensing deals and joint ventures. Oncurious is a joint venture between Oxurion and VIB, the leading life science research institute in Flanders, Belgium. It is focused on developing innovative medicines for treating a broad spectrum of cancers.
The company is developing a portfolio of next-generation immunooncology assets, drawing on seminal work at the VIB-KU Leuven labs of Gabriele Bergers and Massimiliano Mazzone and the VIB-VUB lab of Jo Van Ginderachter. Oncurious’s phase I/IIa clinical trial with TB-403 (anti-PlGF) researches alternative treatment options for medulloblastoma, a rare life-threatening brain tumor in children.