Jan
2021
Oxurion NV appoints Prof Alan Stitt as Chief Scientific Officer
Professor Alan Stitt: “I look forward to working with the team to help advance and broaden Oxurion’s pipeline. This comprises of novel drug candidates with differentiated modes of action targeting DME and dry AMD."
Oct
2020
Oxurion NV appoints Tom Graney, CFA as Chief Financial Officer
Mr. Graney will be responsible for the extension and execution of the financial strategy to support Oxurion's ambitious global growth plans, including the important US market.
Sep
2020
Oxurion NV Reports First Patient Dosed in Phase 2 study evaluating THR-149 for treatment of Diabetic Macular Edema (DME)
Part A of the study will assess the optimal dose from 3 different dose levels of 3 THR-149 injections – read out anticipated around mid-2021.
Aug
2020
Oxurion NV appoints Grace Chang, M.D., Ph.D. as Chief Medical Officer
Dr. Chang will be responsible for leading the Company’s clinical programs for both THR-687 and THR-149 as Oxurion looks to build a world-leading diabetic macular edema (DME) franchise.
Mar
2020
Oxurion NV and Inceptua Group sign global commercial license agreement for Jetrea®
Jan
2020
POSITIVE DATA FROM PHASE 1 STUDY EVALUATING THR-687 FOR DME
THR-687 proved to be well-tolerated and safe, and showed a promising rapid onset of action and prolonged effect on BCVA.
Dec
2019
FOCUS ON NON-VEGF PATHWAYS FOR TREATMENT OF DME
Oxurion announced it will focus its clinical research and development on molecules targeting non-VEGF pathways for the treatment of DME.
Sep
2019
ADDITIONAL POSITIVE DATA FROM PHASE 1 STUDY WITH THR-149
Next to an immediate onset of action and a prolonged effect, this study showed macular volume is correlated with improvement in BCVA.
Aug
2019
MONTH 3 RESULTS OF PHASE 2a STUDY WITH THR-317
The combination therapy of THR-317 with Ranibizumab did not show an increase in mean BCVA at Month 3, except for 2 pre-specified subgroups.
Jul
2019
Positive Topline Data for Phase 1 Results with THR-149 for treating DME
Oxurion NV Reports Positive Topline Phase 1 Results with THR-149, a novel, potent plasma kallikrein inhibitor for the treatment of DME.
Apr
2019
Enrollment complete for Phase 2 clinical study for treating DME
Nov
2018
Oxurion and Beta Therapeutics to develop new heparanase inhibitors for treatment of dry AMD
Sep
2018
First Patient enrolled in Phase II Clinical Study Evaluating THR-317 for treatment of MacTel 1
The study evaluates the efficacy and safety of THR-317 for the treatment of Macular Telangiectasia Type 1. This is a rare disease that affects the macula and can lead to vision loss.
Sep
2018
First Patient enrolled in Phase I Clinical Trial of THR-687 for Treatment of DME
Preclinical studies have demonstrated the role of THR-687 (a pan RGD integrin antagonist) in targeting multiple aspects of retinal disease such as vessel leakage, inflammation, and neovascularization.
Sep
2018
ThromboGenics becomes Oxurion
Apr
2018
Initiation of a Phase II clinical trial evaluating THR-317 incombination with Lucentis (anti-VEGF)
Apr
2018
Positive data from THR-317 Phase I/IIa clinical trial
The data confirm a good safety and tolerability of THR-317, and a clinically relevant biological activity.
Dec
2017
First patients recruited in a Phase I/IIa clinical trial evaluating THR-317 (anti-PlGF) for treatment of DME.
Sep
2017
The company regains full global commercial rights to its product JETREA®
Through an agreement with Novartis, the company regains full global commercial rights to JETREA®. Under the terms of the agreement, the company receives a forthcoming equity investment of €10 million.
May
2016
Oncurious recruits first patient in trial with TB-403
Oncurious recruits its first patient in a Phase I/IIa clinical trial evaluating TB-403 (anti-PlGF) for treatment of medulloblastoma, a rare and life-threatening brain tumor that affects children.
Mar
2016
Investor meeting on novel disease-modifying approaches for diabetic eye disease
The approach has a current focus on diabetic eye disease, mainly diabetic retinopathy/diabetic macular edema, while providing a platform to develop therapies for other ophthalmological indications.
Apr
2015
Creation of Oncurious NV for oncology research
Mar
2015
New pathways: drug development for diabetic eye disease
In 2015, ThromboGenics took a strategic decision to focus its resources on drug development. This decision was driven by the significant potential of our exciting and broad pipeline of next-generation medicines...
Mar
2015
JETREA® approval in over 50 countries worldwide
Mar
2013
EU approval and commercial launch of JETREA® outside the U.S.
European Medicines Agency (EMA) approves JETREA® (Ocriplasmin) for the Treatment of vitreomacular traction (VMT). Alcon launches JETREA in the first markets in Europe.
Jan
2013
Commercial launch of JETREA® in the U.S.
Oct
2012
US FDA Approval for ocriplasmin
The FDA approves ocriplasmin for the treatment of symptomatic vitreomacular adhesion (VMA) in the United States.
Aug
2008
Patrik De Haes, MD, appointed CEO
Aug
2006
Ocriplasmin for vitreoretinal indications
Jul
2006
ThromboGenics listed on Euronext Brussels
Jan
2001
ThromboGenics founded
ThromboGenics broadens the company's R&D scope to include cardiovascular, oncology and ophthalmology programs in-licensed from the University of Leuven and the Flanders Institute for Biotechnology (VIB).
Aug
1991
Thromb-X created
In 1991, Prof. Dr. Désiré Collen and colleagues at Katholieke Universiteit Leuven create Thromb-X NV, with an initial focus on the cardiovascular space.
The engagement of Oxurion reaches far beyond R&D and the promotions of new therapies. Through sustainable partnerships with social initiatives ‑ medical charity, education, culture - Oxurion is committed to increasing patient access to therapies for disorders affecting the back of the eye. Together, we set our sights on preventing vision loss, fighting blindness and providing a better quality of life to those in need.
Retina Global
This international non-profit focused on sustainable solutions for retinal services in underserved areas around the world. Oxurion is currently supporting Retina Global in organizing certification courses in diabetic retinopathy for ophthalmologists and ophthalmology residents in Bolivia. "In underserved areas, there is a great need to treat diabetic retinopathy (DR). Everywhere we go we see people with DR, and often treatment is unaffordable or there simply isn't a retina specialist available. Doctors in these countries don't always have the knowledge or the tools to diagnose these eye diseases", Rajat Agrawal, CEO of Retina Global, explains.
Prevent Blindness
This volunteer eye health and safety organization is dedicated to fighting blindness and saving sight for over a century. Oxurion is currently partnering with Prevent Blindness to encourage people to make their eye health a priority. "Through awareness and education, our goal is to minimize the damaging effects that diabetes can have on vision", Jeff Todd, CEO of Prevent Blindness, says.