Developing next generation treatments to preserve vision for patients with diseases affecting the back of the eye

Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation.

Gao,B.B., Clermont,A., Rook,S., Fonda,S.J., Srinivasan,V.J., Wojtkowski,M., Fujimoto,J.G., Avery,R.L., Arrigg,P.G., Bursell,S.E., Aiello,L.P., and Feener,E.P. 2007. Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat. Med. 13, 181-188.