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Oxurion Completes Enrollment of Phase 1 Clinical Trial Evaluating THR-687, a Novel Pan-RGD Integrin Antagonist, for the Treatment of Diabetic Macular Edema (DME)
Company on Track for Data Read Out by End of 2019
Leuven, Belgium, 4 September 2019 – 7.30 AM CET– Oxurion NV (Euronext Brussels: OXUR), a biopharmaceutical company developing innovative treatments to preserve vision in patients with diabetic eye disease, announces the completion of enrollment of patients in a Phase 1 trial with THR-687.
The open-label, multicenter, dose escalation Phase 1 study is evaluating the safety of a single intravitreal injection of escalating dose levels (3) of THR-687 for the treatment of patients with diabetic macula edema (DME). A total of 12 patients with DME have been enrolled into the US-based study (Clinicaltrials.gov: NCT03666923).
THR-687 is a novel pan-RGD integrin antagonist currently being developed as a potential treatment for patients with diabetic eye disease. Preclinical studies have demonstrated that THR-687 is able to target multiple aspects of retinal vascular disease such as vessel leakage, inflammation, and neovascularization.
Results from this Phase 1 study are expected by end of 2019.
Patrik De Haes, MD, CEO of Oxurion nv, comments: “The completion of patient recruitment means that we are on track to announce the results from this study before the end of 2019. Following the recent positive Phase 1 results with THR-149, we are looking forward to the first clinical data read-out with THR-687, the second VEGF independent molecule and pathway in our innovative DME focused pipeline.”