Developing next generation treatments to preserve vision for patients with diseases affecting the back of the eye

Oxurion NV to Focus Clinical Development on Molecules Targeting VEGF Independent Pathways for Treatment of DME

19 Dec 2019

 

  • Pipeline to focus on the clinical development of THR-149 and THR-687 
  • No further investment in the clinical development of THR-317
  • Commercialization of JETREA to be shifted to distributors/ licensees in marketed territories, patient access to be maintained  

Leuven, Belgium, 19 December 2019 – 17:45 CET – Oxurion NV (Euronext Brussels: OXUR), a biopharmaceutical company developing innovative back of the eye treatments to preserve vision in patients with diabetic eye disease, announces it is to focus its activities on the clinical development of THR-149 and THR-687 as potential VEGF independent treatments for Diabetic Macular Edema (DME). THR-149 is a novel potent plasma kallikrein inhibitor while THR-687 is a Pan-RGD integrin inhibitor, both of which have the potential to treat a broad range of patients with diabetic eye disease.

Oxurion’s clinical pipeline now comprises:

• THR-149, which has shown positive topline Phase 1 results for the treatment of DME. The Company plans to conduct a Phase 2 clinical program, which is expected to start in H1 2020.  

• THR-687, which is in a Phase 1 clinical study assessing it as a treatment for DME. Results from this study are expected in early 2020. 

Patrik De Haes, M.D., CEO of Oxurion, said: “We believe that with THR-149 and THR-687 we have the opportunity to become a global leader in providing retina physicians with novel VEGF independent treatment options for patients with DME. There is a clear need for novel medicines that act via VEGF independent pathways, to address many of the limitations of the VEGF inhibitors, the current standard of care for DME. It is estimated that 40% of DME patients treated with anti-VEGF do not, or sub-optimally respond to anti-VEGF treatment. 

Given the attractiveness of the VEGF independent opportunity and our confidence in our novel compounds’ ability to address this clear unmet medical need, we have decided to make no further investment in the development of THR-317. This reflects the competitive nature of the VEGF market and the mixed Phase 2 results with THR-317 which we released in August 2019. Results from the on-going Mactel-1 study with THR-317 are expected to be presented at a scientific conference in 2020. 

The decisions we have announced today will simplify our organizational structure, allowing us to focus our resources on what we believe are two of the most exciting potential new therapies for diabetic eye disease currently in the clinic.” 

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